Department or Program

Chemistry

Abstract

O-mannosylated glycoproteins are characterized by attachment of an oligosaccharide through mannose to serine or threonine of a protein, and are characterized as m1, m2, or m3, according to their structural motifs. These glycoproteins are found in skeletal muscle tissue, and are in abundance in nerve tissue. They are critical for human development and disruption of the glycoprotein results in various diseases such as muscular dystrophy. However, the functions of these glycoproteins are not well understood, and their extraction from cells is difficult. In order to provide m1, m2, and m3 glycans for further study, we have prepared four mannose building blocks using standard carbohydrate synthesis techniques. In addition, the incorporation of these mannose building blocks into oligosaccharides using automated solution phase oligosaccharide synthesis will be presented in this thesis.

Level of Access

Restricted: Embargoed [Open Access After Expiration]

First Advisor

Koviach-Cote, Jennifer

Date of Graduation

5-2018

Degree Name

Bachelor of Science

Number of Pages

80

Components of Thesis

1 pdf

Embargoed

Available to all on Thursday, May 04, 2023

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