Event Website
http://www.bates.edu/mt-david-summit.xml
Start Date
1-4-2011 1:45 PM
End Date
1-4-2011 3:00 PM
Description
Arsenic is a naturally occurring metal. Exposure to high levels of arsenic in drinking water has been known to cause various types of cancer, skin lesions, and type II diabetes. The EPA sets the legal limit at 10 ppb of arsenic in drinking water, but regions of Taiwan have levels as high as 1,000 ppb. In this study female mice were exposed to 0, 50, or 500 ppb of arsenic in their drinking water prior to mating. At 3 weeks old, offspring were given clean water and their livers were harvested for testing at 4 months of age. The expression of genes known to be important to diabetes was tested. Ten genes were found to be either up- or down-regulated compared to control mice: Acly, Adra1a, Ccr2, Gcgr, Ifng, Il12b, Pck1, Retn, Srebf1, Ucp2. These genes are known to be important to glucose metabolism, lipid metabolism, and chronic inflammation and are thought to play an important role in toxicity of developmental exposures to arsenic.
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Transplacental Exposure to Arsenic in Mice Alters the Expression of Diabetic Genes
Arsenic is a naturally occurring metal. Exposure to high levels of arsenic in drinking water has been known to cause various types of cancer, skin lesions, and type II diabetes. The EPA sets the legal limit at 10 ppb of arsenic in drinking water, but regions of Taiwan have levels as high as 1,000 ppb. In this study female mice were exposed to 0, 50, or 500 ppb of arsenic in their drinking water prior to mating. At 3 weeks old, offspring were given clean water and their livers were harvested for testing at 4 months of age. The expression of genes known to be important to diabetes was tested. Ten genes were found to be either up- or down-regulated compared to control mice: Acly, Adra1a, Ccr2, Gcgr, Ifng, Il12b, Pck1, Retn, Srebf1, Ucp2. These genes are known to be important to glucose metabolism, lipid metabolism, and chronic inflammation and are thought to play an important role in toxicity of developmental exposures to arsenic.
http://scarab.bates.edu/mt_david_summit/MDS2011/02Poster/6