Event Website
http://www.bates.edu/mt-david-summit.xml
Start Date
1-4-2011 1:45 PM
End Date
1-4-2011 3:00 PM
Description
The mechanism of HIV replication holds the lock and key to HIV treatment. Antiretroviral drugs have been designed based on mechanism of inhibition to critical components of the HIV life cycle. However, the short life cycle and the high error rate in genetic replication of HIV leads to rapid mutation and subsequent evasion of designed inhibitors, thus mounting drug resistance in AIDS patients. I reviewed the general classes of the HIV drugs, with a detailed focus on protease inhibitors. HIV-1 protease is an essential enzyme for mature viral proteins that are packaged into new virions to be released from the host cell. The crystallized structure of the HIV-1 protease has allowed for detailed studies in designing inhibitors, yet conservative mutations have led to multiple conformational changes contributing to observed drug resistance. I explored some of the documented mutants of HIV-1 protease in search of patterns contributing to major drug resistance mutations relative to proposed mechanisms of catalysis.
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HIV-1 Protease Mutations Leading to HIV/AIDS Drug Resistance
The mechanism of HIV replication holds the lock and key to HIV treatment. Antiretroviral drugs have been designed based on mechanism of inhibition to critical components of the HIV life cycle. However, the short life cycle and the high error rate in genetic replication of HIV leads to rapid mutation and subsequent evasion of designed inhibitors, thus mounting drug resistance in AIDS patients. I reviewed the general classes of the HIV drugs, with a detailed focus on protease inhibitors. HIV-1 protease is an essential enzyme for mature viral proteins that are packaged into new virions to be released from the host cell. The crystallized structure of the HIV-1 protease has allowed for detailed studies in designing inhibitors, yet conservative mutations have led to multiple conformational changes contributing to observed drug resistance. I explored some of the documented mutants of HIV-1 protease in search of patterns contributing to major drug resistance mutations relative to proposed mechanisms of catalysis.
http://scarab.bates.edu/mt_david_summit/MDS2011/02Poster/8