Publication Title

Journal of Theoretical Biology

Document Type

Article

Department or Program

Mathematics

Publication Date

10-2006

Abstract

How do the normal prion protein (PrP(C)) and infectious prion protein (PrP(Sc)) populations interact in an infected host? To answer this question, we analyse the behavior of the two populations by studying a system of differential equations. The system is constructed under the assumption that PrP(Sc) proliferates using the mechanism of nucleated polymerization. We prove that with parameter input consistent with experimentally determined values, we obtain the persistence of PrP(Sc). We also prove local stability results for the disease steady state, and a global stability result for the disease free steady state. Finally, we give numerical simulations, which are confirmed by experimental data.

Comments

Original version is available from the publisher at: https://doi.org/10.1016/j.jtbi.2006.04.010

Copyright Note

This is the author's version of the work. This publication appears in Bates College's institutional repository by permission of the copyright owner for personal use, not for redistribution.

Required Publisher's Statement

© 2006. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

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