Developmental bisphenol S toxicity in two freshwater animal models

Publication Title

Environmental Toxicology and Pharmacology

Document Type

Article

Department or Program

Biology

Publication Date

11-11-2023

Keywords

Bisphenol S, Danio rerio, Development, Ephydatia muelleri, Freshwater, Toxicity

Abstract

Freshwater animals are exposed to anthropogenic contaminants and are biomonitors of water quality and models of the deleterious impacts of exposure. Sponges, such as Ephydatia muelleri, constantly pump water and are effective indicators of water-soluble contaminants. Zebrafish (Danio rerio), native to Southeast Asia, live in the water column and feed at the water-sediment interface and are exposed to both water-soluble and insoluble contaminants. While sponges and zebrafish diverged ∼700 million years ago, they share common genetic elements, and their response to contaminants can be predictive to a wide-range of animals. An emerging contaminant, bisphenol S, was tested to evaluate its toxicity during development. The toxicity and mechanism(s) of action of BPS is not well known. Water-borne exposures to BPS caused differing hatching rates, morphological changes, and shared gene expression changes of toxicologically-relevant genes. This study shows that BPS causes similarly adverse developmental impacts pointing to some overlapping mechanisms of action.

Comments

Original version is available from the publisher at: https://doi.org/10.1016/j.etap.2023.104311

PubMed ID

37939749

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