Abstract
Rat pups were exposed to 3 days of chronic hypoxia (12% O2) beginning shortly after birth. Ventilation (head-body plethysmography) and metabolic CO2 production (respirometry) were then measured in normoxia (21% O2, balance N2) and during an acute hypoxic challenge (15b minutes in 12% O2, balance N2) immediately following chronic hypoxia and after 1, 4-5, and 7 d in room air; different individuals were studied at each age. The linked data files contain the individual-level ventilation and CO2 production data. The full methods and summary data are available in the peer-reviewed article:
Bavis RW, Lee DI, Kinnally AC, Puxton PE., 2024. Recovery of ventilatory and metabolic responses to hypoxia in neonatal rats after chronic hypoxia. Respiratory Physiology and Neurobiology, 329: 104317. https://doi.org/10.1016/j.resp.2024.104317
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Keywords
Chronic hypoxia, Control of breathing, Developmental plasticity, Biphasic hypoxic ventilatory response, Ventilatory acclimatization to hypoxia, Carotid body, Deacclimation, Heterokairy, Acclimation, Hypoxic hypometabolism, Phenotypic plasticity
DOI
https://doi.org/10.26780/2024.003.0001
Creative Commons License
This work is licensed under a Creative Commons Attribution-Share Alike 4.0 International License.
Funding Source(s)
Research reported here was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20 GM103423.
Citation Information
Bavis, Ryan W.; Lee, Darya I.; Kinnally, Annie C.; and Buxton, Payton E., "Individual-level Data to Accompany “Recovery of Ventilatory and Metabolic Responses to Hypoxia in Neonatal Rats After Chronic Hypoxia”" (2024). SCARAB Data Repository. 2.
https://scarab.bates.edu/datasets/2
Publication Date
2024
Open Access
Available to all.
Additional Information
Linked files (CSV format) include a list of abbreviations used in the spreadsheets as well as separate spreadsheets for each time point (immediately following chronic hypoxia and after 1, 4-5, and 7 d in room air). At each time point, breathing data are provided for baseline and minutes 1, 3, 5, 10, and 15 of the acute hypoxic exposure. CO2 production data are provided for baseline and minute 15 only.