Abstract
Sprague Dawley rats were exposed to chronic hyperoxia (60% O 2 ) as juveniles or as adults. Ventilation (whole-body plethysmography) and metabolic rate (respirometry) were then measured in normoxia (21% O 2 , balance N 2 ) and during acute hypoxic or hypercapnic challenges (15 – 20 minutes in 12% O 2 or 7% CO 2 , respectively) immediately following chronic hyperoxia or after a period of recovery in room air. The linked data files contain the individual-level ventilation and metabolism data. The full methods and summary data are available in the peer-reviewed article:
Bavis RW, Danielson MD, Dufour G, Hanus J, Pratt AE, Tobin KE, 2025. Respiratory plasticity induced by chronic hyperoxia in juvenile and adult rats. Respiratory Physiology and Neurobiology 333: 104386. [DOI: https://doi.org/10.1016/j.resp.2024.104386]
This article will be freely be available to download from PubMed Central on 2/1/2026 here: https://pubmed.ncbi.nlm.nih.gov/39732308/
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Keywords
Control of breathing; Phenotypic plasticity; Hyperoxia; Hypoxic ventilatory response; Hypercapnic ventilatory response; Deacclimation
DOI
https://doi.org/10.26780/2025.003.0001
Creative Commons License
This work is licensed under a Creative Commons Attribution-Share Alike 4.0 International License.
Funding Source(s)
Research reported here was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20 GM103423.
Citation Information
Bavis, Ryan; Danielson, Matthew D.; Dufour, Gemma; Hanus, Julia; Pratt, Ashley E.; and Tobin, Kristina E., "Individual-level Data to Accompany “Respiratory Plasticity Induced by Chronic Hyperoxia in Juvenile and Adult Rats”" (2025). SCARAB Data Repository. 3.
https://scarab.bates.edu/datasets/3
Publication Date
2025
Additional Information
Linked files (CSV format) include separate spreadsheets for each experiment.